Integrated current readout circuit and DMFET array for label-free detection of cancer marker

Abstract

This paper describes a current readout platform designed for dielectric modulated field effect transistor (DMFET) arrays to detect a prostate cancer marker without labeling. A chip of 16 DMFET array has been fabricated as a biosensor cartridge. Standard 0.35 mum CMOS technology has been used to fabricate the readout circuit which includes a current integrator and a 10-bit single-slope analog-to-digital converter (ADC). The prostate cancer marker has been successfully detected by monitoring a change of DMFET current with aid of the fabricated readout circuitry.