PROTECTIVE RAGE FRAGMENT INHIBITS AMYLOID BETA OLIGOMERIZATION

Abstract

The article discusses the involvement of beta-amyloid in the mechanism of the protective action of the synthetic RAGE fragment. It was shown that the peptide is able to suppress the formation of oligomers and fibrils of beta-amyloid in solution. This confirms the hypothesis that the protective activity of the peptide is associated with its ability to inhibit the process of oligomerization of beta-amyloid.