Liver Function In Patients With Homozygous Sickle Cell Disease (Hbss) – Effect Of Hbv Infection

Annals of Biomedical Sciences Pub Date : 2008-01-30 DOI:10.4314/ABS.V3I1.40661

U. Nnebe-Agumadu, P. Abiodun

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Abstract

Using the sensitive ELISA technique, 213 patients with sickle cell anemia (112 males and 101 females) aged 6 months to 18 years were screened for Hepatitis B infection using Hepatitis B surface antigen (HBsAg) and antibody to Hepatitis B core antigen. A biochemical evaluation of liver function was carried out on all patients using Alanine and Aspartate transaninases, alkaline phosphate and serum bilirubin. The patients positive for HBV markers had their liver function tests compared with those of patients negative for the HBV markers. No statistically significant difference attributable to the presence of HBV was observed between the mean values of the serum enzymes amongst the groups. Isolated elevations in enzymes levels were, however, noted and randomly distributed in the various groups of patients with and without HBV markers. The abnormalities in liver function tests did not show any peculiar trend with the sex and age of patients has normal or slight elevation in liver enzymes with a moderate rise in serum bilirubin especially the direct reacting component. Keywords : Liver functions, Sickle cell disease, Hepatitis B Annals of Biomedical Science Vol. 3 (1&2) 2004: pp. 54-60

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纯合子镰状细胞病(Hbss)患者的肝功能- Hbv感染的影响

采用灵敏的ELISA技术对213例6月龄~ 18岁的镰状细胞性贫血患者(男112例，女101例)进行乙型肝炎表面抗原(HBsAg)和乙型肝炎核心抗原抗体的筛查。采用谷丙转氨酶、天冬氨酸转氨酶、碱性磷酸酶和血清胆红素对患者肝功能进行生化评价。HBV标志物阳性的患者与HBV标志物阴性的患者进行肝功能检查。各组间血清酶的平均值与HBV的存在无统计学差异。然而，孤立的酶水平升高被注意到，并随机分布在有和没有HBV标志物的不同组的患者中。肝功能检查异常未见患者性别、年龄的特殊趋势，肝酶正常或轻度升高，血清胆红素(尤其是直接反应成分)中度升高。关键词:肝功能，镰状细胞病，乙型肝炎，生物医学科学年鉴第3卷(1&2)2004:第54-60页

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Annals of Biomedical Sciences

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