Controller and observer design for anti-angiogenic tumor treatment

Abstract

This paper concerns design and numerical simulation for anti-angiogenic tumor treatment for the tumors cause women breast cancer. The paper first provides an exact model knowledge controller to drive tumor volume to a desired trajectory, and then explains the design of an observer for the carrying capacity of the vascular network. Lyapunov-like arguments are used to prove the stability of the system. Numerical simulation results are also presented to show the feasibility of the proposed controller and observer.