Optimal impulse control of systems with control constraints and application to HIV treatment

Abstract

In this paper, conditions for optimal impulse control of an impulsive system with constraints on control are derived. These hold for a system whose states can be changed instantaneously at discrete times with impulses while a continuous control is being applied between those times. The conditions derived are applied to the problem of optimal HIV treatment. Simulation results are presented to show the treatment procedure. The results obtained show that the intervention method developed leads to good results