Assessment Of Serum Cyanocobalamin Level And Importance In Patients With Hematological Malignancies

Turkish Journal of Clinics and Laboratory Pub Date : 2023-06-30 DOI:10.18663/tjcl.1225685

Esra Zeynelgil, Özlem Doğan, B. Sağlam, Mehmet Asıl

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Abstract

ABSTRACT Aim: In our study, we planned to investigate the effect of serum cyanocobalamin (Vitamin B12) levels at the time of diagnosis in patients with various hematological malignancies. Patients and Methods: Two hundred and one patients between 18-75 years old diagnosed with various hematological malignancies and 30 healthy controls applying to outpatient and inpatient clinics of Hematology Department in Necmettin Erbakan University Meram Faculty of Medicine between 2010-2014 years were included in the study. Demographic and clinical data and laboratory findings of the patients included in the study were recorded retrospectively. Results: A total of 231 patients, 132 men (57.1%) and 99 women (42.9%), were included in our study, of which 201 were patients and 30 were healthy controls. The mean serum vitamin B12 concentration of all patients was found as 344.9 ± 279.0 pg/mL. When vitamin B12 levels were analyzed according to diagnostic groups, it was found to be highest in CML (596.0 ± 428.3 pg / mL) and ALL (524.5 ± 442.6 pg / mL) patients and lowest in AML patients (240.9 ± 178, 0 pg / mL); the difference was statistically significant (p

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血液恶性肿瘤患者血清氰钴胺素水平的评估及其重要性

摘要:目的:在我们的研究中，我们计划探讨血清氰钴胺素(维生素B12)水平在诊断时对各种血液系统恶性肿瘤患者的影响。患者与方法:选取2010-2014年在Necmettin Erbakan大学Meram医学院血液内科门诊和住院就诊的218例年龄在18-75岁之间的各种血液恶性肿瘤患者和30名健康对照者。回顾性记录纳入研究的患者的人口学、临床资料和实验室结果。结果:共纳入231例患者，其中男性132例(占57.1%)，女性99例(占42.9%)，其中患者201例，健康对照30例。所有患者的平均血清维生素B12浓度为344.9±279.0 pg/mL。按诊断组分析维生素B12水平，CML患者最高(596.0±428.3 pg / mL)， ALL患者最高(524.5±442.6 pg / mL)， AML患者最低(240.9±178.0 pg / mL);差异有统计学意义(p

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Turkish Journal of Clinics and Laboratory

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