Infusible Platelet Membrane may be Effective and Safe: A Mini Review

Abstract

Our recent experiences have shown that major platelet adhesion (CD41b) and aggregation (CD41/CD61) receptors presence on the membrane with platelet factor 3 activity in lyophilized IPM preparation [18]. As well, our newer animal studies of IPM have demonstrated its efficacy with dose-dependent property [19,20], without any pyrogenic side effect [21] or toxicity [22]. Nasiri et al results in rabbits showed that the maximum hemostatic effectiveness was at 2 hours after IPM administration, while Chao et al had been reported 4 hours [11]. Also, the major aggregation receptor of platelets CD41/CD61 was present on our IPM, but was absent in Chao experiment may be due to our modified IPM processing with lower detrimental effects on platelet membrane receptors. These findings confirms more improving of its hemostatic effectiveness.