Pathogenesis of hypogammaglobulinaemia with thymoma and late-onset hypogammaglobulinaemia.

Abstract

mitogen and IgM measured seven days later in g±g/ml. To assess suppressor cells equal numbers (6 x 10') of normal T cells or T cells from a patient with thymoma were added. The data show that the patient's T cells, whether treated (Tmito) or untreated (T) with mitomycin C, suppressed immunoglobulin production while normal T cells caused an increase. This experiment was repeated with similar results (de Gast et al., 1979a).