Investigating the Highlights of Pluripotent Stem Cells in Diabetes Type 2

Abstract

Type 2 Diabetes Mellitus (T2DM) is a serious global pandemic and has a leading position among the causes of mortality. Diabetes mellitus is a heterogeneous disorder that both genetic background and environment can affect it. It is characterized by hyperglycemia due to a reduction in insulin secretion and action. In recent years, studies have proved that Human Pluripotent Stem Cells (hPSCs) have a remarkable role in showing genetic signs of this disease and using in clinical studies and treatment to show promising preliminary results. Results: The published studies in 2022 examine the role of pluripotent stem cells in diabetes type 2 treatments. Conclusion: The results of most studies show that studying and examining pluripotent stem cells can be practical and pave the way for drug treatment effects on different variants of diabetes type 2. The aim of this mini-review essay is to highlight the strength and shortcomings of pluripotent stem cells’ role in the molecular mechanism of this disease.