Lipid emulsions in the treatment of acute poisoning in the Clinic of Toxicology at the Naval Hospital-Varna, Military Medical Academy-Sofia

G. Kehayova, S. Zlateva, P. Marinov
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Abstract

Introduction: Acute drug intoxications are a serious problem worldwide. The damage to the cardiovascular system is severe and sometimes refractory to standard resuscitation therapy. In recent years, interest has increased in the role of lipid emulsions (LEs) as a potential antidote in patients with severe myocardial damage caused by toxic doses of lipophilic drugs. Aims: Clinical analysis of the cardioprotective effects of applied LEs at the Clinic of Toxicology at the Naval Hospital-Varna, Military Medical Academy-Sofia, as an antidote for the treatment of some acute poisoning with a cardiotoxic syndrome. Materials and Methods: The subject of the study were 26 patients with acute cardiotoxic lipophilic drug intoxications treated with LEs at the Clinic of Toxicology at the Naval Hospital-Varna in the period 2016-2018. Illnesses and medications administered to patients are derived from the medical documentation. Results: A three-year study was conducted in patients with acute exogenous intoxications treated with LEs at the Clinic of Toxicology at the Naval Hospital-Varna in regard to their demographics, concomitant diseases and prescribed treatment during their stay. Rapid recovery of patients' vital signs, short hospital stay and lack of adverse effects of LE administration were found. Conclusion: The good clinical results obtained by us will help the implementation of LE in a number of lipophilic intoxications causing toxic cardiovascular damages, including those with hemodynamic instability.
脂质乳剂在瓦尔纳海军医院、索非亚军事医学院毒理学诊所治疗急性中毒中的应用
急性药物中毒是一个严重的世界性问题。对心血管系统的损害是严重的,有时对标准的复苏治疗是难治的。近年来,人们对脂质乳剂(LEs)作为一种潜在的解毒剂在由毒性剂量的亲脂性药物引起的严重心肌损伤患者中的作用越来越感兴趣。目的:临床分析索非亚军事医学院瓦尔纳海军医院毒理学诊所应用LEs作为治疗急性中毒合并心脏毒性综合征的解毒剂的心脏保护作用。材料与方法:以2016-2018年在瓦尔纳海军医院毒理学诊所接受LEs治疗的26例急性心毒性亲脂性药物中毒患者为研究对象。病人所患疾病和服用的药物均来自医疗记录。结果:对瓦尔纳海军医院毒理学诊所接受LEs治疗的急性外源性中毒患者进行了为期三年的研究,涉及其人口统计学、伴随疾病和住院期间的处方治疗。患者生命体征恢复快,住院时间短,给药后无不良反应。结论:我们获得的良好临床结果将有助于在一些引起毒性心血管损害的亲脂性中毒,包括血液动力学不稳定的患者中实施LE。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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