SINGLE CASCADE SIMULATING MOVING BED PROCESS WITH DIFFERENT COLUMNS CONFIGURATION FOR BINARY SEPARATION OF AMINO ACIDS

Abstract

In this work, the binary separation of phenylalanine and tryptophan with different chromatographic column configurations was studied. Although the operational flow scheme is important in simulating moving bed (SMB) process, limitations in design of the scheme remain. The non-linear separation system is modeled with the Aspen Chromatography simulator in a four zone SMB on the basis of performance parameters such as purity, enrichment, productivity and yield. In addition, the separation of the binary system is also examined for a modified conventional SMB process, that is, Varicol. Furthermore, we investigated how subdivisions of chromatographic bed in a zone affect the wave dynamics and separation performance. Results of this study can provide guidance in operational flow schemes with different options of chromatographic column configurations for the design of SMB and Varicol processes for this binary separation or for a specific objective in the selected performance parameters.