Features of the extrapancreatic action of glibenclamide in cerebral ischemia in the highlands

Abstract

The features of remodeling of the components of the vascular plexus and the microcirculatory bed of the brain in cerebral ischemia in the highlands are studied, the features of the action of glibenclamide on these structures are presented. It is shown that the sulfonylurea receptor 1 (SUR 1) in the highlands becomes more sensitive to glibenclamide than in the low mountains. Key words: brain, ischemia, glibenclamide, highlands.