CHEST CT SCORE IN COVID-19 PATIENTS: THE RELATIONSHIP BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO, MONOCYTE, LACTATE DEHYDROGENASE, ALBUMIN AND FERRITIN

Phoenix Medical Journal Pub Date : 2023-01-20 DOI:10.38175/phnx.1199180

B. Çil, I. Demir, M. Kabak, I. Hocanlı, M. Taylan, Mustafa Fi̇danten

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Abstract

Objective: Various Laboratory and vital parameters, including leukopenia, lymphopenia, neutrophil/lymphocyte ratio elevation, lactate dehydrogenase elevation, D-dimer and ferritin elevation, and low albumin can be used in the diagnosis and assessment of the severity of COVID-19 infection . Methods: The chest computed tomography (CT) scores, lymphopenia, neutrophil/lymphocyte ratio, neutrophil, lymphocyte, lactate dehydrogenase, albumin, C-reactive protein, white blood cells, platelets, basophil, eosinophil, monocytes, procalcitonin, D-dimer, ferritin, ages, genders, hospitalization units, oxygen-free fingertip saturations in room air, additional diseases and symptoms of 693 patients diagnosed with COVID-19 were recorded. The parameters of the patients were compared according to the severity of the chest CT score. Results: As a result of this study neutrophil/lymphocyte ratio was found to be significantly higher in the severe group when compared to the moderate group and the mild group. As chest CT score increased, lactate dehydrogenase level was higher at a statistically significant level in the severe group than in the mild group. Albumin levels were found to be lower in the severe group at a statistically significant level than in the mild group. Monocyte levels were found to be lower in the severe group at a statistically significant level when compared to the moderate and mild groups. Ferritin level was higher in the severe group at a statistically significant level when compared to the moderate and mild groups. When the practical effectiveness of using hematological and biochemical parameters to differentiate patients with severe CT scores from non-severe patients based on the chest CT score of the patients was examined by using the ROC Analysis, it was found that the neutrophil/lymphocyte ratio value had the strongest predictive ability (AUC, 0.787, SD=0.057, P

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新冠肺炎患者胸部ct评分:中性粒细胞-淋巴细胞比值、单核细胞、乳酸脱氢酶、白蛋白、铁蛋白的关系

目的:白细胞减少、淋巴细胞减少、中性粒细胞/淋巴细胞比值升高、乳酸脱氢酶升高、d -二聚体和铁蛋白升高、低白蛋白等各项实验室及生命指标可用于诊断和评估COVID-19感染的严重程度。方法:记录693例确诊新冠肺炎患者的胸部CT评分、淋巴细胞减少、中性粒细胞/淋巴细胞比值、中性粒细胞、淋巴细胞、乳酸脱氢酶、白蛋白、c反应蛋白、白细胞、血小板、嗜碱性粒细胞、嗜酸性粒细胞、单核细胞、降钙素原、d -二聚体、铁蛋白、年龄、性别、住院单位、室内空气中无氧手指饱和度、附加疾病及症状。根据患者胸部CT评分的严重程度比较各参数。结果:本研究发现，重度组中性粒细胞/淋巴细胞比值明显高于中度组和轻度组。随着胸部CT评分的升高，重度组乳酸脱氢酶水平高于轻度组，且差异有统计学意义。重症组的白蛋白水平低于轻度组，且有统计学意义。与中度和轻度组相比，重度组单核细胞水平较低，具有统计学意义。重度组铁蛋白水平高于中度组和轻度组，差异有统计学意义。当应用ROC分析检验根据患者胸部CT评分用血清学生化参数区分重症CT评分与非重症CT评分的实际有效性时，发现中性粒细胞/淋巴细胞比值值的预测能力最强(AUC, 0.787, SD=0.057, P

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Phoenix Medical Journal

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