Tumours of the haemopoietic system

Abstract

This chapter covers tumours of the haemopoietic system. Hodgkin lymphoma: clinical features, diagnosis, and staging, treatment of early and advanced stages, management of recurrence, and long-term toxicities and fertility issues are discussed. It outlines current treatment strategies that aim to maintain the high cure rates reached for all stages of the disease with chemotherapy and radiotherapy while further improving outcome and minimizing or preventing therapy-induced complications, such as infertility, cardiopulmonary toxicity, and second malignancies. For non-Hodgkin lymphoma, the clinical features, treatment of low-grade disease, diffuse large B-cell lymphoma, mantle cell lymphoma, cutaneous non-Hodgkin lymphomas, and extranodal involvement are discussed. Diagnosis with molecular profiling is used to define and stratify approaches to treatment for adult acute lymphoblastic leukaemia; adult acute myeloid leukaemia; chronic myeloid leukaemia; chronic lymphocytic leukaemia; hairy cell leukaemia; myelodysplastic syndrome; multiple myeloma; solitary plasmacytoma; monoclonal gammopathy of undetermined significance; smouldering myeloma; Waldenstrom’s macroglobulinaemia; amyloidosis and POEM syndrome; heavy chain disease; and histiocyte disorders.