Early stage dynamics modeling of the feed-forward loops with miRNA

Abstract

MicroRNAs or miRNAs are small non-coding RNA molecules, containing about 20 nucleotides only, but they are very important in regulatory gene networks. miRNAs repress target protein production at post-transcriptional level, but real mechanism of regulation is not absolutely clear. Moreover, the models may show the same steady state concentrations of components for different biological cases, and only study the early stage dynamics can help in choosing the most appropriate model.