Effects of flunitrazepam-ketamine mixed injection for inhalation induction.

Abstract

Experiments were performed to investigate the effects of inhalation induction in dogs. The combination is preceded by administration of 0.025 mg/kg of atropine sulfate subcutaneously. The dosage is 0.1 mg/kg of flunitrazepam and 5 mg/kg of ketamine, administered intravenously mixed in one syringe. The results were as follows :1. Jaw reflex and auricular reflex were cd not disappear completely but intubation was performed easily. 2. Decrease of arterial blood pressure was controlled in comparison with flunitrazepam administration alone.3. Less obvious changes in electrocardiogram were found in it.4. Immediately after administration, respiration rate and arterial oxygen tension were slightly decrease, therefor using it, in advance anesthesia, great care and inhalation oxygen must be taken.5. The above : It was suggested that flunitrazepam and ketamine administered intravenously mixed injection were useful means.