Effects of Lipophilic and Hydrophilic leaf extracts of Portulaca oleracea Linn. (Purslane) on male reproductive parameters in albino rats

American Journal of Physiology, Biochemistry and Pharmacology Pub Date : 1900-01-01 DOI:10.5455/AJPBP.20190124101830

V. Obinna, H. Kagbo, G. O. Agu

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引用次数: 8

Abstract

Objectives: To supply scientific information / literature on the use of P.oleracea in enhancing fertility in males; either to validate or to refute this folkloric use. This study investigated the effect of the lipophilic and hydrophilic leaf extracts of Portulaca oleracea on male reproductive parameters. Methods: The extracts were obtained using two extracting solvents chloroform and 80% aqueous methanol in succession. Experimental animals were randomly divided into 7 groups of 16 rats each. Group A (control) received 0.5ml 20% Tween 80 (vehicle), groups B, C and D received 125, 250 and 500 mg/kg of the lipophilic extract respectively and E, F and G received 125, 250 and 500 mg/kg of the hydrophilic extract respectively for 60 days. On days 14, 28, 42 and 60; four rats from each group were weighed and anaesthetized for sample collection. Blood (for testosterone), testes (weight and histomorphology) and sperm cells from caudal epididymis (for semen analysis) were collected. Results: Both extracts had no significant (p>0.05) effect on testicular weight and histomorphology, and sperm cell characteristics but caused a significant (p

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马齿苋叶提取物的亲脂和亲水作用。马齿苋对白化大鼠雄性生殖参数的影响

目的:为利用马鞭草提高男性生育能力提供科学信息/文献;要么证实，要么反驳这种民间用法。研究马齿苋亲水性和亲脂性叶提取物对雄性生殖参数的影响。方法:分别用氯仿和80%甲醇水溶液进行提取。实验动物随机分为7组，每组16只大鼠。A组(对照组)给予20% Tween 80 0.5ml(对照)，B、C、D组分别给予125、250、500 mg/kg亲脂提取物，E、F、G组分别给予125、250、500 mg/kg亲水提取物，疗程60 D。第14、28、42、60天;每组取4只大鼠称重，麻醉后取标本。采集血液(睾酮)、睾丸(重量和组织形态学)和尾侧附睾精子细胞(精液分析)。结果:两种提取物对大鼠睾丸重量、组织形态及精子细胞特征均无显著影响(p < 0.05)

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American Journal of Physiology, Biochemistry and Pharmacology

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