Feasibility Study of Mesoporous Silica Nanoparticles Permeability through the Cancer Microtissues

Abstract

Microtissues are 3D structures created to stimulate the real environment of the cell line (i.e.MCF-7). In this study, mesoporous silica with different surface modifications nanopartciles (MSN, MSN-PEI and MSN-PEI-SUCC) were added to breast cell line-generated microtissue. Thereafter, the penetration of MSNs in microtissue and the effect on the morphological tissue was investigated, and MSN-surface functinalization and increasing concentration dependent effects were observed.