Features of the immune status of patients with community-acquired viral pneumonia which was complicated by development of the acute respiratory distress syndrome

Abstract

30 patients with community-acquired viral pneumonia with laboratory confirmed diagnoses virus of an influenza A H1N1 (n=17) and a parainfluenza (n=13), complicated by the development of the acute respiratory a distress syndrome are examined. At these patients was established: decrease of proliferative activity of T lymphocytes, of quantity of serum immunoglobulins of a class M and G and active formation of immune complexes. At the died patients direct correlation dependence of quantity of the mononuclear cells which entered an apoptosis with the relative number of natural killers and absolute quantity of CD8+ of cytotoxic T-lymphocytes is established (R=0,71 and R=0,67 respectively, р < 0,05). It confirms a role of cellular immune reactions in development of the activation induced death of lymphocytes at serious viral pneumonia