In silico comparasion of 11 different radioisotopes for palliative treatment of bone metastases

2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG) Pub Date : 2015-02-01 DOI:10.1109/ENBENG.2015.7088832

F. G. Guerra Liberal, R. S. Tavares Joao Manuel, A. Tavares

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Abstract

Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology. However, the choice of which bone seeking agent to use is not consensual. Computer simulation is a simple and practical solution to study and to compare a variety of radioisotopes. This study aimed to compare 11 different radioisotopes currently in use or under research. Hence, computational models were used to estimate the percentage of deoxyribonucleic acid damage, the probability of correct DNA repair, and the radiation-induced cellular effects post-irradiation. 223Ra alpha particles, 177Lu beta minus particles, and 170Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by 89Sr and 153Sm, was higher than 177Lu beta minus particles and 223Ra alpha particles. Findings reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases.

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11种不同放射性同位素对骨转移姑息性治疗的计算机比较

多年来，骨寻找放射性示踪剂对骨转移的姑息性治疗已成为肿瘤学治疗资源的一部分。然而，选择使用哪种寻骨剂并不是双方同意的。计算机模拟是研究和比较各种放射性同位素的一种简单实用的方法。这项研究旨在比较目前正在使用或正在研究的11种不同的放射性同位素。因此，使用计算模型来估计脱氧核糖核酸损伤的百分比、正确DNA修复的概率以及辐照后辐射诱导的细胞效应。223Ra α粒子、177Lu β -粒子和170Tm β -粒子诱导的细胞死亡在所有研究的粒子和放射性同位素中最高。用89Sr和153Sm发射的β -粒子辐照后的细胞存活率高于177Lu β -粒子和223Ra α粒子。本文报道的研究结果可能会促进未来的体外和体内实验，比较不同的放射性核素对骨转移的姑息性治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)

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