Drug Dosing in Renal Failure

Abstract

Optimal dosing of medications can be influenced by many factors. These factors are important to consider because the therapeutic effects of drugs are frequently concentration dependent and can even result in toxicity. One factor of great importance is the pharmacokinetics of a medication. Pharmacokinetics is the way in which medications move through the body during absorption, distribution, metabolism, and excretion. This chapter focuses on the excretion of medications as it relates to renal function.