The amino acid sequence of the light chain variable region of a canine myeloma immunoglobulin: Evidence that the vk subgroups predated mammalian speciation

Richard L. Wasserman, J. Donald Capra
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引用次数: 3

Abstract

The complete amino acid sequence of the variable region of a kappa light chain derived from a canine myeloma immunoglobulin is presented. The sequence is more than 80% homologous to the human kappa variable region Cum the prototype of the human VKII subgroup and is the first example of a non-human kappa chain which can be easily classified as a subgroup other than VKI. The finding confirms a previous prediction that genes encoding kappa subgroups predated mammalian speciation.

犬骨髓瘤免疫球蛋白轻链可变区氨基酸序列:vk亚群早于哺乳动物物种形成的证据
完整的氨基酸序列的kappa轻链从犬骨髓瘤免疫球蛋白衍生的可变区域。该序列与人类kappa可变区和人类VKII亚群的原型同源性超过80%,是非人类kappa链的第一个例子,可以很容易地归类为VKI以外的亚群。这一发现证实了先前的预测,即编码kappa亚群的基因早于哺乳动物物种形成。
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