Minimal Change Nephrotic Syndrome with Acute Kidney Injury after the Administration of Pfizer-BioNTech COVID-19 Vaccine.

IF 1 Q4 INFECTIOUS DISEASES
Erdinc Gulumsek, Dilan Damla Ozturk, Huseyin Ali Ozturk, Tayyibe Saler, Kivilcim Eren Erdogan, Ahmed Muhammad Bashir, Hilmi Erdem Sumbul
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Abstract

Nephrotic syndrome progresses with various metabolic disturbances, such as proteinuria over 3.5 grams in 24 hours, hypoalbuminemia, and hypercoagulability. Patients usually complain about diffuse edema throughout the body, which is secondary to hypoalbuminemia. It has many primary and secondary causes. Patients may require a renal biopsy to confirm the diagnosis. Besides, many secondary causes of nephrotic syndrome should be examined and excluded. Although many vaccines were developed due to the COVID-19, many side effects are still reported because of the Pfizer-BioNTech COVID-19 vaccine (COVID-19 mRNA and BNT162b2), which is widely used in Turkey. This study examines a case of nephrotic syndrome with acute renal injury after Pfizer-BioNTech vaccine.

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辉瑞- biontech COVID-19疫苗接种后急性肾损伤的微小变化肾病综合征
肾病综合征的进展伴随着各种代谢紊乱,如24小时内蛋白尿超过3.5克、低白蛋白血症和高凝血性。患者通常主诉为全身弥漫性水肿,继发于低白蛋白血症。它有许多主要和次要的原因。患者可能需要肾活检来确认诊断。此外,肾病综合征的许多继发原因应检查和排除。尽管针对COVID-19开发了许多疫苗,但由于在土耳其广泛使用的辉瑞- biontech COVID-19疫苗(COVID-19 mRNA和BNT162b2),仍有许多副作用的报道。本研究报告一例在辉瑞生物技术(Pfizer-BioNTech)疫苗后并发急性肾损伤的肾病综合征。
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