Major Histocompatibility Complex Class II HLA-DRB1 Allelic Epitopes in Fibromyalgia.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-01-01 DOI:10.2174/2772270816666220321162802

Basant K Puri, Gary S Lee, Armin Schwarzbach

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Abstract

Background: Preliminary evidence has pointed an association of the gene HLA-DRB1 with fibromyalgia. HLA-DRB1 alleles carrying the shared or susceptibility epitope encoding the five-amino acid motif QKRAA, QRRAA or RRRAA in positions 70 to 74 of the major histocompatibility complex class II DRβ chain are associated with several autoimmune diseases.

Objective: The objective of this study was to test the hypothesis that susceptibility epitope-encoding HLA-DRB1 alleles are associated with fibromyalgia.

Methods: Using a case-control design, the prevalence of susceptibility epitope-encoding HLADRB1 alleles in 27 white Caucasian patients fulfilling the revised diagnostic criteria for fibromyalgia of the American College of Rheumatology was compared with that in 27 white Caucasian ageand sex-matched healthy controls.

Results: 13 (48%) of the fibromyalgia patients had susceptibility epitope-coding HLA-DRB1 alleles compared with 15 (56%) of the controls (P = 0.785). The DRB1*01 allele encoding the protective epitope 70-DERAA-74 motif was found in one of the control subjects; none of the fibromyalgia patients had such a protective epitope.

Conclusion: While the present study does not provide evidence supporting the potential role of HLA-DRB1 in the etiology of fibromyalgia, it does not exclude the possibility that there is a polygenic component to a putative genetic causative role.

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纤维肌痛的主要组织相容性复合体II类HLA-DRB1等位基因表位。

背景:初步证据表明HLA-DRB1基因与纤维肌痛有关。HLA-DRB1等位基因携带编码主要组织相容性复合体II类DRβ链第70至74位的5个氨基酸基序QKRAA、QRRAA或RRRAA的共享或易感表位，与多种自身免疫性疾病相关。目的:本研究的目的是验证易感性表位编码HLA-DRB1等位基因与纤维肌痛相关的假设。方法:采用病例对照设计，比较27例符合美国风湿病学会修订的纤维肌痛诊断标准的白种人患者与27例年龄和性别匹配的白种人健康对照者的易感表位编码HLADRB1等位基因的患病率。结果:纤维肌痛患者中13例(48%)存在易感表位编码HLA-DRB1等位基因，对照组中15例(56%)存在易感表位编码等位基因(P = 0.785)。在1例对照组中发现编码保护性表位70-DERAA-74基序的DRB1*01等位基因;没有纤维肌痛患者有这样的保护性表位。结论:虽然目前的研究没有提供证据支持HLA-DRB1在纤维肌痛病因学中的潜在作用，但它不排除存在多基因成分的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.