Racial Disparities and Cardiometabolic Risk: New Horizons of Intervention and Prevention.

IF 5.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Current Diabetes Reports Pub Date : 2022-03-01 Epub Date: 2022-02-17 DOI:10.1007/s11892-022-01451-6
Eftitan Y Akam, Akua A Nuako, Afkera K Daniel, Fatima Cody Stanford
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引用次数: 0

Abstract

Purpose of review: Cardiometabolic diseases are a leading cause of morbidity and mortality in the USA and disproportionately impact racial and ethnic minorities. Multiple factors contribute to this disparity including genetic and socioeconomic factors, the latter of which contributes to disparities both through systemic barriers such as healthcare access and by directly impacting metabolism through epigenetics and environment-related alterations in the gut microbiome. This review will discuss advances in medicine that can be used to identify, prognosticate, and treat cardiometabolic diseases, and how these may be used to address existing disparities.

Recent findings: There is growing research aimed at identifying novel cardiometabolic disease targets and expanding the use of existing pharmacotherapies based on comorbidities. Advances in metabolomics and genomics can give insight into an individual's unique biochemical profile, providing the means for earlier identification of disease and specific treatment targets. Moreover, developments in telehealth and related medical device technologies can expand access to underserved minority populations and improve control of chronic conditions such as diabetes and hypertension. Precision medicine may be integral to bridging the racial gap in cardiometabolic disease outcomes. Developments in genomics, metabolomics, wearable medical devices, and telehealth can result in personalized treatments for patients that account for the socioeconomic and genetic factors that contribute to poor health outcomes in minorities. As research in this field rapidly progresses, special efforts must be made to ensure inclusion of racial and ethnic minority populations in clinical research and equal access to all treatment modalities.

种族差异与心脏代谢风险:干预与预防的新视野》(Racial Disparities and Cardiometabolic Risk: New Horizons of Intervention and Prevention.
审查目的:在美国,心脏代谢疾病是发病和死亡的主要原因,对少数种族和族裔的影响尤为严重。造成这种差异的因素有多种,包括遗传因素和社会经济因素,后者通过系统性障碍(如获得医疗保健的机会)以及通过表观遗传学和肠道微生物组中与环境相关的改变直接影响新陈代谢,从而造成差异。本综述将讨论可用于识别、预后和治疗心脏代谢疾病的医学进展,以及如何利用这些进展来解决现有的差异:最近的研究结果:旨在确定新型心脏代谢疾病靶点并根据合并症扩大现有药物疗法使用范围的研究日益增多。代谢组学和基因组学的进步可以让人们深入了解个人独特的生化特征,为更早地确定疾病和特定的治疗目标提供了手段。此外,远程医疗和相关医疗设备技术的发展可以扩大服务不足的少数民族人群的就医范围,改善糖尿病和高血压等慢性病的控制。精准医疗可能是缩小心脏代谢疾病治疗效果种族差距不可或缺的一部分。基因组学、代谢组学、可穿戴医疗设备和远程医疗的发展可以为患者提供个性化治疗,考虑到导致少数族裔健康状况不良的社会经济和遗传因素。随着该领域研究的快速发展,必须做出特别努力,确保将少数种族和少数族裔人口纳入临床研究,并确保他们有平等机会获得所有治疗方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
52
审稿时长
6-12 weeks
期刊介绍: The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of diabetes epidemiology, pathophysiology, and management. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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