The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2022-12-01 DOI:10.1080/03014460.2022.2134453

Parviz Azimnasab-Sorkhabi, Maryam Soltani-Asl, José Roberto Kfoury, Petra Algenstaedt, Hakan Farzin Mehmetzade, Yashar Hashemi Aghdam

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引用次数: 3

Abstract

Background: Diabetes comprises a serious disease with significant growth in the number of cases in recent years. Here, we cover the gap in information between leptin (LEP) and type 1 diabetes in the Iranian population.

Aim: To recognise LEP G2548A and LEP receptor Q223R polymorphisms in Iranian people and their association with type 1 diabetes susceptibility.

Subjects and methods: Characteristics such as fasting blood sugar (FBS) were measured in 80 control non-diabetic individuals and 89 diabetic patients. Moreover, LEP G2548A and LEP receptor Q223R polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique.

Results: The frequency of the A allele was nearly three times greater in diabetes patients than in the control group. In addition, in the diabetes group, the AA genotype was five times greater than in the control group (p < 0.01). Furthermore, AA and AA + AG genotype models had higher FBS levels than the GG + AG and GG genotype models, respectively (p < 0.01).

Conclusion: The LEP G2548A polymorphism could be related to type 1 diabetes susceptibility, but not LEPR Q223R polymorphism in the Iranian population. Importantly, further studies are essential to examine the impact of LEP G2548A and LEPR Q223R polymorphisms in the endocrinology area.

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伊朗西北部人群瘦素及其受体多态性对1型糖尿病的影响

背景:糖尿病是一种严重的疾病，近年来病例数量显著增加。在这里，我们涵盖了伊朗人群中瘦素(LEP)和1型糖尿病之间的信息差距。目的:了解伊朗人LEP G2548A和LEP受体Q223R多态性及其与1型糖尿病易感性的关系。对象与方法:测定80例非糖尿病对照和89例糖尿病患者的空腹血糖(FBS)。此外，利用聚合酶链反应-限制性片段长度多态性技术对LEP G2548A和LEP受体Q223R多态性进行基因分型。结果:A等位基因在糖尿病患者中的出现频率是对照组的近3倍。此外，糖尿病组AA基因型是对照组的5倍(p p)。结论:伊朗人群中LEP G2548A多态性可能与1型糖尿病易感性有关，但与LEPR Q223R多态性无关。重要的是，进一步研究LEP G2548A和LEPR Q223R多态性在内分泌学领域的影响是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.