Hepatocellular Damage and Severity of COVID-19 Infection in Iraqi Patients: A Biochemical Study.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zainab Nazar Hasan Anber, Basil Oead Mohammed Saleh, Mohammed Waheab Al-Obidy
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引用次数: 0

Abstract

Background: Infection with COVID-19 can cause hepatic damages. Here, we aimed to examine the effect of COVID-19 infection on the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, and procalcitonin (PCT) concentrations as markers to evaluate the liver function.

Methods: In this study, 56 patients infected with COVID- 19 and 28 healthy controls was recruited in Private Nursing Home Hospital of the Medical City, Baghdad. Patients were subdivided according to disease severity into severe and non-severe groups.

Results: The results showed that the mean±SD value of serum AST activity and serum PCT concentrations were elevated significantly in severe group in comparison to healthy control, (p< 0.01, p< 0.001) respectively. Also, the mean ±SD value of serum ALT activity was higher in severe group compared to the healthy subjects and non-severe ones, significantly (p< 0.0001, p< 0.003) respectively. While the mean value of serum albumin concentration of severe patients and non-severe group were significantly decreased compared to healthy subjects. The receiver operating characteristic curve (ROC) revealed that ROC value of albumin (0.992) differentiates between non-severe infected patients and healthy subjects, while the ROC value of serum ALT activity (0.735) differentiates between severe COVID-19 patients and non- severe ones.

Conclusion: Changes of liver function parameters in COVID-19 patients were mild to moderate and measurement of serum ALT activity is the best biomarker in differentiation between non-severe patients and severe ones and albumin concentration is excellent in discrimination between patients and controls.

伊拉克患者COVID-19感染的肝细胞损伤和严重程度:生化研究
背景:COVID-19感染可导致肝脏损害。本研究旨在探讨COVID-19感染对血清天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、白蛋白和降钙素原(PCT)浓度的影响,以此作为评估肝功能的指标。方法:在巴格达医疗城私立养老院医院招募56例新冠肺炎患者和28例健康对照。根据病情严重程度将患者细分为严重组和非严重组。结果:重症组血清AST活性和PCT浓度均值±SD值较健康对照组显著升高(p< 0.01, p< 0.001)。重度组血清ALT活性均值±SD值高于正常组和非重度组,差异均有统计学意义(p< 0.0001, p< 0.003)。而重症组和非重症组的血清白蛋白浓度均值较健康人显著降低。受试者工作特征曲线(ROC)显示,白蛋白的ROC值(0.992)区分非重症感染者与健康者,血清ALT活性的ROC值(0.735)区分重症感染者与非重症感染者。结论:新冠肺炎患者肝功能指标变化为轻至中度,血清ALT活性测定是区分非重症和重症患者的最佳生物标志物,白蛋白浓度在区分患者和对照组方面具有良好的效果。
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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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