Case report: Urothelial carcinoma of the renal pelvis with trophoblastic differentiation: A rare case report and review of literature.

IF 2.3 4区医学 Q3 ONCOLOGY

Pathology & Oncology Research Pub Date : 2023-01-01 DOI:10.3389/pore.2023.1610856

Zhuo Wang, Jinsui Wang, Wenwen Zhang, Daoying Wang, Xiaojun Wang, Xiaoqin Liang

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Abstract

We report a rare case of urothelial carcinoma (UC) of the renal pelvis with trophoblastic differentiation that occurred in a 55-year-old male patient. The patient presented with gross hematuria and paroxysmal lumbago pain 5 months ago. The enhanced computed tomography (CT) scan demonstrated a large space occupying lesion in the left kidney and multiple retroperitoneal lymph node enlargements. Histologically, high-grade infiltrating urothelial carcinoma (HGUC) contained giant cells which were positive for beta-human chorionic gonadotropin (β-hCG). Three weeks after resection, positron emission tomography and computed tomography (PET-CT) scan showed multiple nodules of metastasis in the left renal region, extensive systemic muscle, bone, lymph node, liver and bilateral lung metastases. The patient underwent bladder perfusion chemotherapy and gemcitabine combined with cisplatin chemotherapy regimens. This is the eighth documented case of UC of the renal pelvis with trophoblastic differentiation. Due to its rarity and extremely poor prognosis, it is important to clarify the characteristics of the disease and make an accurate and prompt diagnosis.

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病例报告:肾盂尿路上皮癌伴滋养细胞分化:一例罕见病例报告及文献复习。

我们报告一例罕见的肾盂尿路上皮癌(UC)伴滋养细胞分化，发生在一位55岁男性患者。患者5个月前出现肉眼血尿和阵发性腰痛。增强计算机断层扫描(CT)显示左肾大面积占位性病变和多个腹膜后淋巴结肿大。组织学上，高级别浸润性尿路上皮癌(HGUC)含有β-人绒毛膜促性腺激素(β-hCG)阳性的巨细胞。术后3周，正电子发射断层扫描和计算机断层扫描(PET-CT)显示左肾区多发转移结节，广泛的全身肌肉、骨、淋巴结、肝脏和双侧肺转移。患者接受膀胱灌注化疗及吉西他滨联合顺铂化疗方案。这是第8例肾盂UC伴滋养细胞分化的病例。由于其罕见且预后极差，因此明确疾病的特征并做出准确及时的诊断非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology & Oncology Research 医学-病理学

CiteScore

6.30

自引率

0.00%

发文量

134

审稿时长

4-8 weeks

期刊介绍： Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.