Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-01-20 DOI:10.5937/jomb0-34017

Marija Stanković, Valentina Đorđević, Andrija Tomović, Ljudmila Nagorni-Obradović, Nataša Petrović-Stanojević, Mirjana Kovač, Dragica Radojković

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引用次数: 0

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder with unexplained heritability. Interactions of genetic and environmental factors are thought to be crucial in COPD. So, we aim to examine interactions of the endothelial nitric oxide synthase (eNOS) and angiotensin converting enzyme (ACE) genes and cigarette smoking in COPD.

Methods: The eNOS G 894T and ACE ID variants were analyzed in 122 COPD patients and 200 controls from Serbia. The effect of the variants on COPD was assessed by logistic regression. Interactions between eNOS, ACE and cigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzed in silico.

Results: No effect of the eNOS G 894T and ACE ID variants on COPD was found in our study. Gene-gene interaction between the eN OS T T and A CE D was identified (p=0.033) in COPD. The interaction is realized within the complex network of biochemical pathways. Gene-environment interactions between the eNOS T and cigarette smoking (p=0.013), and the ACE II and cigarette smoking (p=0.009) were detected in COPD in our study.

Conclusions: This is the first research to reveal interactions of the eNOS and ACE genes and cigarette smoking in COPD progressing our understanding of COPD heritability and contributing to the development of appropriate treatments.

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eNOS和ACE基因与慢性阻塞性肺疾病吸烟的相互作用

背景:慢性阻塞性肺疾病(COPD)是一种遗传性不明的复杂疾病。遗传和环境因素的相互作用被认为是COPD的关键。因此，我们的目的是研究内皮型一氧化氮合酶(eNOS)和血管紧张素转换酶(ACE)基因与COPD患者吸烟的相互作用。方法:对来自塞尔维亚的122例COPD患者和200例对照进行eNOS G 894T和ACE ID变异分析。通过logistic回归评估这些变异对COPD的影响。采用病例-对照模型评估eNOS、ACE与COPD患者吸烟之间的相互作用。在计算机上分析了基因之间的相互作用。结果:在我们的研究中未发现eNOS G 894T和ACE ID变异对COPD的影响。在COPD患者中发现enos T T和A CE D之间的基因-基因相互作用(p=0.033)。这种相互作用是在生化途径的复杂网络中实现的。在COPD患者中检测到eNOS T与吸烟之间的基因-环境相互作用(p=0.013)， ACE II与吸烟之间的基因-环境相互作用(p=0.009)。结论:这是第一个揭示eNOS和ACE基因与吸烟在COPD中的相互作用的研究，促进了我们对COPD遗传性的理解，并有助于开发适当的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.