Perspectives of cyanobacterial cell factories.

IF 2.9 3区 生物学 Q2 PLANT SCIENCES
Photosynthesis Research Pub Date : 2024-12-01 Epub Date: 2023-11-15 DOI:10.1007/s11120-023-01056-4
Anastasios Melis, Diego Alberto Hidalgo Martinez, Nico Betterle
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引用次数: 0

Abstract

Cyanobacteria are prokaryotic photosynthetic microorganisms that can generate, in addition to biomass, useful chemicals and proteins/enzymes, essentially from sunlight, carbon dioxide, and water. Selected aspects of cyanobacterial production (isoprenoids and high-value proteins) and scale-up methods suitable for product generation and downstream processing are addressed in this review. The work focuses on the challenge and promise of specialty chemicals and proteins production, with isoprenoid products and biopharma proteins as study cases, and the challenges encountered in the expression of recombinant proteins/enzymes, which underline the essence of synthetic biology with these microorganisms. Progress and the current state-of-the-art in these targeted topics are emphasized.

Abstract Image

蓝藻细胞工厂的前景。
蓝藻是一种原核光合微生物,除了生物量外,还能产生有用的化学物质和蛋白质/酶,主要来自阳光、二氧化碳和水。本文综述了蓝藻生产(类异戊二烯和高价值蛋白质)的选定方面以及适用于产品生成和下游加工的放大方法。工作重点是特殊化学品和蛋白质生产的挑战和前景,以类异戊二烯产品和生物制药蛋白为研究案例,以及重组蛋白/酶表达中遇到的挑战,这些挑战强调了这些微生物合成生物学的本质。强调了这些目标主题的进展和当前状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Photosynthesis Research
Photosynthesis Research 生物-植物科学
CiteScore
6.90
自引率
8.10%
发文量
91
审稿时长
4.5 months
期刊介绍: Photosynthesis Research is an international journal open to papers of merit dealing with both basic and applied aspects of photosynthesis. It covers all aspects of photosynthesis research, including, but not limited to, light absorption and emission, excitation energy transfer, primary photochemistry, model systems, membrane components, protein complexes, electron transport, photophosphorylation, carbon assimilation, regulatory phenomena, molecular biology, environmental and ecological aspects, photorespiration, and bacterial and algal photosynthesis.
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