Usefulness of lead isotopes analysis in a pediatric case of chronic lead poisoning.

IF 1.4 4区医学 Q4 ENVIRONMENTAL SCIENCES

Archives of Environmental & Occupational Health Pub Date : 2023-01-01 DOI:10.1080/19338244.2022.2063241

L Dufayet, J Poupon, D Vodovar, J Langrand

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引用次数: 0

Abstract

Identifying the source of lead is a key measure in the management of childhood lead poisoning. In cases with multiple potential sources or with unusual circumstances, this identification can be complex. By comparing the lead isotopic ratios (IRs) between the potential sources and the blood sample from the patient, it is possible to identify which source caused the poisoning. We report here the case of a 13-years-old girl, screened for lead poisoning as she was known to eat paint chips from two walls in her apartment. Her blood lead level was 395 µg/L, and the environmental investigation came back negative. X-ray fluorescence found lead concentration in paints to be below the regulatory threshold of 1 mg/cm². As there was no other potential source of lead exposure in this case, a comparative analysis of the IRs of lead between the child's blood and two presumed sources (bathroom and kitchen paints) was performed. This analysis confirmed the source of lead intoxication to be the paints in the apartment, mostly from the bathroom wall.

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铅同位素分析在儿童慢性铅中毒病例中的作用。

查明铅的来源是儿童铅中毒管理的关键措施。在有多个潜在来源或特殊情况的情况下，这种识别可能很复杂。通过比较潜在来源和患者血液样本之间的铅同位素比率(IRs)，可以确定引起中毒的来源。我们在此报道一名13岁女孩的病例，她因吃了公寓两面墙上的油漆碎片而被查出铅中毒。血铅395µg/L，环境检查结果为阴性。x射线荧光检测发现，油漆中的铅浓度低于每平方厘米1毫克的规定阈值。由于在本病例中没有其他潜在的铅接触源，因此对儿童血液和两种假定来源(浴室和厨房油漆)之间的铅IRs进行了比较分析。这一分析证实了铅中毒的来源是公寓里的油漆，主要来自浴室的墙壁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Environmental & Occupational Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.