Do all patients with primary refractory/first relapse of HL need autologous stem cell transplant?

IF 2.9 3区 教育学 Q1 EDUCATION, SCIENTIFIC DISCIPLINES
Alison J Moskowitz
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引用次数: 2

Abstract

The standard approach to treatment of primary refractory/first relapse of classical Hodgkin lymphoma (cHL) is administration of second-line therapy (SLT) followed by consolidation with high-dose therapy and autologous hematopoietic cell transplantation (HDT/AHCT). Historically, this approach cured about 50% of patients. Due to improvements in supportive care, positron emission tomography-adaptive strategies, and incorporation of novel agents into SLT, contemporary studies show that about 75% of patients with primary refractory or first relapse of cHL can be cured. Recent studies evaluating incorporation of PD-1 blockade in SLT appear to show even further improvement in remission rates and bring into question whether an aggressive approach that includes HDT/AHCT is needed for everyone. To address this question, several ongoing studies are beginning to explore the possibility of avoiding or delaying HDT/AHCT for patients with primary refractory or first relapse of cHL.

所有原发性难治性/首次复发的HL患者都需要自体干细胞移植吗?
治疗原发性难治性/首次复发的经典霍奇金淋巴瘤(cHL)的标准方法是给予二线治疗(SLT),然后辅以大剂量治疗和自体造血细胞移植(HDT/AHCT)。从历史上看,这种方法治愈了大约50%的患者。由于支持治疗的改进、正电子发射层析成像适应策略以及SLT中新型药物的应用,当代研究表明,大约75%的原发性难治性或首次复发的cHL患者可以治愈。最近的研究评估了在SLT中结合PD-1阻断剂似乎显示缓解率进一步改善,并提出了包括HDT/AHCT在内的积极方法是否适用于所有人的问题。为了解决这个问题,一些正在进行的研究开始探索对原发性难治性或首次复发的cHL患者避免或延迟HDT/AHCT的可能性。
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来源期刊
Hematology. American Society of Hematology. Education Program
Hematology. American Society of Hematology. Education Program EDUCATION, SCIENTIFIC DISCIPLINES-HEMATOLOGY
CiteScore
4.70
自引率
3.30%
发文量
0
期刊介绍: Hematology, the ASH Education Program, is published annually by the American Society of Hematology (ASH) in one volume per year.
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