Clonal hematopoiesis and atherosclerotic cardiovascular disease: A primer

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE
María A. Zuriaga , José J. Fuster
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引用次数: 2

Abstract

Despite current standards of care, a considerable risk of atherosclerotic cardiovascular disease remains in both primary and secondary prevention. In this setting, clonal hematopoiesis driven by somatic mutations has recently emerged as a relatively common, potent and independent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Experimental studies in mice suggest that mutations in TET2 and JAK2, which are among the most common in clonal hematopoiesis, increase inflammation and are causally connected to accelerated atherosclerosis development, which may explain the link between clonal hematopoiesis and increased cardiovascular risk. In this review, we provide an overview of our current understanding of this emerging cardiovascular risk factor.

克隆造血和动脉粥样硬化性心血管疾病:引物
尽管有目前的护理标准,但动脉粥样硬化性心血管疾病的相当大的风险仍然存在于一级和二级预防中。在这种情况下,由体细胞突变驱动的克隆性造血最近成为动脉粥样硬化性心血管疾病和其他心血管疾病的一个相对常见、有效和独立的风险因素。对小鼠的实验研究表明,在克隆性造血中最常见的TET2和JAK2突变会增加炎症,并与动脉粥样硬化的加速发展有因果关系,这可能解释了克隆性造血与心血管风险增加之间的联系。在这篇综述中,我们概述了我们目前对这一新兴心血管风险因素的理解。
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来源期刊
Clinica e Investigacion en Arteriosclerosis
Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-
CiteScore
3.20
自引率
6.20%
发文量
44
审稿时长
40 days
期刊介绍: La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.
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