3D Printed Personalized Colon-targeted Tablets: A Novel Approach in Ulcerative Colitis Management.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2024-01-01 DOI:10.2174/1567201821666230915150544

Yachana Mishra, Vijay Mishra, Alaa A A Aljabali, Mohamed El-Tanani, Gowhar A Naikoo, Nitin Charbe, Sai Raghuveer Chava, Murtaza M Tambuwala

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引用次数: 0

Abstract

Ulcerative colitis (UC) and Crohn's disease (CD) are two types of idiopathic inflammatory bowel disease (IBD) that are increasing in frequency and incidence worldwide, particularly in highly industrialized countries. Conventional tablets struggle to effectively deliver anti-inflammatory drugs since the inflammation is localized in different areas of the colon in each patient. The goal of 3D printing technology in pharmaceutics is to create personalized drug delivery systems (DDS) that are tailored to each individual's specific needs. This review provides an overview of existing 3D printing processes, with a focus on extrusion-based technologies, which have received the most attention. Personalized pharmaceutical products offer numerous benefits to patients worldwide, and 3D printing technology is becoming more affordable every day. Custom manufacturing of 3D printed tablets provides innovative ideas for developing a tailored colon DDS. In the future, 3D printing could be used to manufacture personalized tablets for UC patients based on the location of inflammation in the colon, resulting in improved therapeutic outcomes and a better quality of life.

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3D 打印个性化结肠靶向药片：治疗溃疡性结肠炎的新方法

溃疡性结肠炎（UC）和克罗恩病（CD）是特发性炎症性肠病（IBD）的两种类型，在全球范围内，尤其是在高度工业化国家，这两种疾病的发病率越来越高。由于每位患者的炎症都分布在结肠的不同部位，因此传统药片很难有效地输送抗炎药物。三维打印技术在制药学中的目标是创建个性化的给药系统（DDS），以满足每个人的特定需求。本综述概述了现有的 3D 打印工艺，重点介绍最受关注的基于挤压的技术。个性化医药产品为全球患者带来了诸多益处，而三维打印技术的价格也日趋合理。3D 打印药片的定制生产为开发量身定制的结肠 DDS 提供了创新思路。未来，3D 打印技术可用于根据结肠炎症的位置为 UC 患者制造个性化药片，从而提高治疗效果和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.