Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria.

Luis D'Marco, Xavier Guerra-Torres, Iris Viejo, Luis Lopez-Romero, Alejandra Yugueros, Valmore Bermídez
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引用次数: 1

Abstract

Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage kidney disease worldwide. Its pathogenic mechanism is complex, and it can affect the entire structures of the kidneys such as the glomerulus, tubules and interstitium. Currently, the urinary albumin excretion rate and the estimated glomerular filtration rate are widely accepted as diagnostic criteria. However, some studies have reported a different or non-classical clinical course of DKD, with some patients showing declined kidney function with normal levels of albuminuria, known as the 'non-albuminuric DKD' phenotype. The pathogenesis of this phenotype remains unclear, but some clinical and pathological features have been postulated. This review explores the evidence regarding this topic.

Abstract Image

非白蛋白尿糖尿病肾病的表型:超越白蛋白尿。
糖尿病肾病(DKD)是世界范围内慢性和终末期肾病的主要原因。其致病机制复杂,可累及肾小球、肾小管、肾间质等整个肾脏结构。目前,尿白蛋白排泄率和估算的肾小球滤过率被广泛接受为诊断标准。然而,一些研究报道了不同的或非经典的DKD临床病程,一些患者表现出肾功能下降,蛋白尿水平正常,被称为“非蛋白尿DKD”表型。这种表型的发病机制尚不清楚,但一些临床和病理特征已被假设。这篇综述探讨了关于这一主题的证据。
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