Oropharyngeal colostrum administration in neonates with gastroschisis: a randomized clinical trial.

Hellen Porto Pimenta, Adriana Duarte Rocha, Aline Carnevale Lia Dias Guimarães, Ana Carolina Carioca da Costa, Maria Elisabeth Lopes Moreira
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Abstract

Objective: To evaluate the effect of colostrum therapy on days to start a suckling diet in newborns diagnosed with simple gastroschisis.

Methods: Randomized clinical trial with newborns diagnosed with simple gastroschisis at a federal hospital in Rio de Janeiro who were randomized to receive oropharyngeal administration of 0.2mL of colostrum or a "sham procedure" during the first 3 days of life. The analysis included clinical outcomes such as days without food, days with parenteral feeding, days until the start of enteral feeding, days to reach complete enteral feeding, sepsis and length of hospital stay.

Results: The onset of oral feeding (suction) in patients with simple gastroschisis in both groups occurred at a median of 15 days.

Conclusion: The present study showed that there were no significant differences in the use of colostrum therapy and the number of days to the start of enteral feeding and suction diet between groups of newborns with simple gastroschisis.

Abstract Image

新生儿腹裂患者的口咽初乳给药:一项随机临床试验。
目的:评价在诊断为单纯腹裂的新生儿开始吃奶的日子里使用初乳治疗的效果。方法:在里约热内卢一家联邦医院对诊断为单纯腹裂的新生儿进行随机临床试验,这些新生儿在出生后的头3天内被随机分配接受0.2mL初乳口咽给药或“假手术”。分析包括临床结果,如无食物天数、肠外喂养天数、开始肠内喂养前的天数、完全肠内喂养的天数、败血症和住院时间。结果:两组单纯腹裂患者的口腔喂养(抽吸)开始时间均为15天。结论:本研究表明,患有单纯腹裂的新生儿在使用初乳治疗以及开始肠内喂养和抽吸饮食的天数方面没有显著差异。
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