Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development.

IF 4.5 3区医学 Q2 IMMUNOLOGY

Current Opinion in HIV and AIDS Pub Date : 2023-09-01 Epub Date: 2023-07-18 DOI:10.1097/COH.0000000000000812

Shaown Bhattacharyya, Charles R Crain, Benjamin Goldberg, Gaurav D Gaiha

{"title":"Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development.","authors":"Shaown Bhattacharyya, Charles R Crain, Benjamin Goldberg, Gaurav D Gaiha","doi":"10.1097/COH.0000000000000812","DOIUrl":null,"url":null,"abstract":"Purpose of review: CD8+ T cell responses are a key component of the host immune response to human immunodeficiency virus (HIV) but vary significantly across individuals with distinct clinical outcomes. These differences help inform the qualitative features of HIV-specific CD8+ T cells that we should aim to induce by vaccination.Recent findings: We review previous and more recent findings on the features of dysfunctional and functional CD8+ T cell responses that develop in individuals with uncontrolled and controlled HIV infection, with particular emphasis on proliferation, cytotoxic effector function, epitope specificity, and responses in lymph nodes. We also discuss the implications of these findings for both prophylactic and therapeutic T cell vaccine development within the context of T cell vaccine trials.Summary: The induction of HIV specific CD8+ T cell responses is an important goal of ongoing vaccine efforts. Emerging data on the key features of CD8+ T cell responses that distinguish individuals who spontaneously control from those with progressive disease continues to provide key guidance.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"18 5","pages":"257-263"},"PeriodicalIF":4.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503300/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in HIV and AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/COH.0000000000000812","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: CD8+ T cell responses are a key component of the host immune response to human immunodeficiency virus (HIV) but vary significantly across individuals with distinct clinical outcomes. These differences help inform the qualitative features of HIV-specific CD8+ T cells that we should aim to induce by vaccination.

Recent findings: We review previous and more recent findings on the features of dysfunctional and functional CD8+ T cell responses that develop in individuals with uncontrolled and controlled HIV infection, with particular emphasis on proliferation, cytotoxic effector function, epitope specificity, and responses in lymph nodes. We also discuss the implications of these findings for both prophylactic and therapeutic T cell vaccine development within the context of T cell vaccine trials.

Summary: The induction of HIV specific CD8+ T cell responses is an important goal of ongoing vaccine efforts. Emerging data on the key features of CD8+ T cell responses that distinguish individuals who spontaneously control from those with progressive disease continues to provide key guidance.

查看原文本刊更多论文

功能性和失调性 CD8+ T 细胞的特征，以指导 HIV 疫苗的开发。

综述的目的：CD8+ T细胞反应是宿主对人类免疫缺陷病毒（HIV）免疫反应的关键组成部分，但不同个体的临床结果差异很大。这些差异有助于我们了解通过接种疫苗诱导的 HIV 特异性 CD8+ T 细胞的质量特征：我们回顾了以前和最近关于未控制和已控制 HIV 感染者体内功能失调和功能性 CD8+ T 细胞反应特征的研究结果，特别强调了增殖、细胞毒性效应器功能、表位特异性和淋巴结中的反应。我们还在 T 细胞疫苗试验的背景下讨论了这些发现对预防性和治疗性 T 细胞疫苗开发的影响。摘要：诱导 HIV 特异性 CD8+ T 细胞应答是当前疫苗工作的一个重要目标。有关 CD8+ T 细胞应答的关键特征的新数据将继续为区分自发控制和疾病进展的个体提供重要指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

7.40

自引率

7.30%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.