Diagnostic value of elevated serum angiotensin-converting enzyme and lymphopenia in patients with granulomatous hepatitis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-13 DOI:10.36141/svdld.v40i3.14221

Thomas El Jammal, François Dhelft, Pierre Pradat, François Bailly, Fabien Zoulim, Arnaud Hot, Maxime Fauter, Ayoub Drissi-Bakhkhat, Isabelle Durieu, Jean-Christophe Lega, Yvan Jamilloux, Pascal Sève

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Abstract

Background and aim: Granulomatous hepatitis (GH) is associated with various aetiologies, especially inflammatory and infectious disorders. Sarcoidosis is a granulomatous disease in which the liver is the fourth most affected organ. Since epithelioid cell granulomas are not specific to sarcoidosis and since most patients with hepatic sarcoidosis are asymptomatic, valuable diagnostic biomarkers are needed to support the diagnosis of sarcoidosis. This study proposes to assess the diagnostic value of serum angiotensin converting enzyme (sACE) and lymphopenia in GH for sarcoidosis.

Methods: We retrospectively analyzed the records of 90 patients referred to the internal medicine or hepatogastroenterology departments of the Lyon University Hospital (Lyon, France) between March 2002 and January 2020 in a context of GH.

Results: In our tertiary center, 38 patients with sarcoidosis were identified among 73 patients with GH. Lymphopenia had a high specificity (85.7%), which increased when combined with elevated (97.0%). Interestingly, specificity increased in patients under 50 years old (100%).

Conclusions: Those results suggests that lymphopenia and sACE may be valuable biomarkers for sarcoidosis diagnosis in GH when combined, especially in younger patients.

Abstract Image

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血清血管紧张素转换酶升高和淋巴细胞减少对肉芽肿性肝炎的诊断价值。

背景和目的：肉芽肿性肝炎（GH）与各种病因有关，尤其是炎症和感染性疾病。结节病是一种肉芽肿性疾病，其中肝脏是第四大受累器官。由于上皮样细胞肉芽肿不是结节病特有的，而且大多数肝结节病患者都没有症状，因此需要有价值的诊断生物标志物来支持结节病的诊断。本研究旨在评估血清血管紧张素转换酶（sACE）和GH中淋巴细胞减少症对结节病的诊断价值。方法：我们回顾性分析了2002年3月至2020年1月期间在法国里昂里昂大学医院内科或肝胃肠病科转诊的90名GH患者的记录，当与升高（97.0%）相结合时，特异性增加。有趣的是，50岁以下患者的特异性增加（100%）。结论：这些结果表明，淋巴细胞减少症和sACE可能是诊断GH结节病的有价值的生物标志物，尤其是在年轻患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.