Comparison of Tranexamic Acid and Dexmedetomidine on Bleeding in Endoscopic Sinus Surgery.

Q3 Medicine
Mohammad Saeed Ahmadi, Javaneh Jahanshahi, Farnaz Hashemian, Ahmad Reza Salimbahrani, Negar Haghi, Elham Khanlarzadeh
{"title":"Comparison of Tranexamic Acid and Dexmedetomidine on Bleeding in Endoscopic Sinus Surgery.","authors":"Mohammad Saeed Ahmadi,&nbsp;Javaneh Jahanshahi,&nbsp;Farnaz Hashemian,&nbsp;Ahmad Reza Salimbahrani,&nbsp;Negar Haghi,&nbsp;Elham Khanlarzadeh","doi":"10.22038/IJORL.2022.64361.3203","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The quality of the surgical field during the surgery is impaired when bleeding occurs. This study compared the effect of tranexamic acid and dexmedetomidine on the rate of bleeding during endoscopic sinus surgery (ESS).</p><p><strong>Materials and methods: </strong>In this one-blind clinical trial, 72 patients with chronic rhinosinusitis who were candidates for ESS at Be'sat Hospital in Hamedan were randomly assigned to two groups. Group A received dexmedetomidine at a dose of 1μg/kg, and group B received tranexamic acid at a dose of 10mg/kg immediately after induction of anesthesia intravenously within 15 minutes. The two groups were evaluated and compared regarding the quality of the surgery field with the Boezaart scale, volume of intraoperative bleeding, hemodynamic changes, and complications up to 90 minutes after the beginning of surgery.</p><p><strong>Results: </strong>The mean volume of intraoperative bleeding in group A (181.67±86.66) was significantly higher than in group B (110.28±61.23) (P =0.000). At 15, 30, and 60 minutes, the quality of the surgical field in group B was better than group A (P =0.038), while at 90 minutes, there was no statistically significant difference (P =0.450). The mean arterial pressure in group A at 15 minutes was higher than in group B (P=0.003); at 60 and 90 minutes, it was lower, and the difference was statistically significant (P =0.01). On the other hand, in 30 minutes, the mean arterial pressure in group A was higher than in group B, without a significant difference (P =0.07). Moreover, there was no statistically significant difference between the average surgery time (P = 0.25) and the frequency of complications (P =0.405).</p><p><strong>Conclusions: </strong>Based on the results, tranexamic acid is preferable to injectable dexmedetomidine to control and reduce bleeding during ESS.</p>","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 126","pages":"49-56"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872265/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Otorhinolaryngology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/IJORL.2022.64361.3203","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: The quality of the surgical field during the surgery is impaired when bleeding occurs. This study compared the effect of tranexamic acid and dexmedetomidine on the rate of bleeding during endoscopic sinus surgery (ESS).

Materials and methods: In this one-blind clinical trial, 72 patients with chronic rhinosinusitis who were candidates for ESS at Be'sat Hospital in Hamedan were randomly assigned to two groups. Group A received dexmedetomidine at a dose of 1μg/kg, and group B received tranexamic acid at a dose of 10mg/kg immediately after induction of anesthesia intravenously within 15 minutes. The two groups were evaluated and compared regarding the quality of the surgery field with the Boezaart scale, volume of intraoperative bleeding, hemodynamic changes, and complications up to 90 minutes after the beginning of surgery.

Results: The mean volume of intraoperative bleeding in group A (181.67±86.66) was significantly higher than in group B (110.28±61.23) (P =0.000). At 15, 30, and 60 minutes, the quality of the surgical field in group B was better than group A (P =0.038), while at 90 minutes, there was no statistically significant difference (P =0.450). The mean arterial pressure in group A at 15 minutes was higher than in group B (P=0.003); at 60 and 90 minutes, it was lower, and the difference was statistically significant (P =0.01). On the other hand, in 30 minutes, the mean arterial pressure in group A was higher than in group B, without a significant difference (P =0.07). Moreover, there was no statistically significant difference between the average surgery time (P = 0.25) and the frequency of complications (P =0.405).

Conclusions: Based on the results, tranexamic acid is preferable to injectable dexmedetomidine to control and reduce bleeding during ESS.

氨甲环酸与右美托咪定治疗鼻内镜手术出血的比较。
手术过程中,出血会影响手术视野的质量。本研究比较了氨甲环酸和右美托咪定对内镜鼻窦手术(ESS)出血率的影响。材料和方法:在这项单盲临床试验中,72例Hamedan Be'sat医院的慢性鼻窦炎患者被随机分为两组。A组给予右美托咪定1μg/kg剂量,B组麻醉诱导后立即在15分钟内静脉给予氨甲环酸10mg/kg剂量。采用Boezaart评分法对两组患者手术野质量、术中出血量、血流动力学变化及术后90分钟并发症进行评价和比较。结果:A组平均术中出血量(181.67±86.66)明显高于B组(110.28±61.23)(P =0.000)。15、30、60分钟时,B组手术野质量优于A组(P =0.038), 90分钟时,差异无统计学意义(P =0.450)。A组15 min平均动脉压高于B组(P=0.003);60、90分钟时较低,差异有统计学意义(P =0.01)。另一方面,在30分钟内,A组的平均动脉压高于B组,但差异无统计学意义(P =0.07)。平均手术时间(P = 0.25)与并发症发生频率(P =0.405)比较,差异无统计学意义。结论:氨甲环酸比注射右美托咪定更能控制和减少ESS术中出血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Iranian Journal of Otorhinolaryngology
Iranian Journal of Otorhinolaryngology Medicine-Otorhinolaryngology
CiteScore
1.30
自引率
0.00%
发文量
72
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信