[Ways to solve the problem of cross-reactions during immunochromatographic examination of biological objects].

Q4 Medicine
P S Vikman, A S Zhuravleva, O Yu Strelova, A N Grebenyuk
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引用次数: 0

Abstract

The purpose of this review is to study the causes of cross-reactions of a number of drugs (mebeverine, phenibut, tropicamide, ramipril, metoprolol, phenylephrine, sertraline, chloropyramine and diphenhydramine) during the preliminary stage of laboratory diagnostics by immunochromatographic method and to propose a possible algorithm for solving this problem. Conducting a hair study in order to identify the fact of the use of psychoactive substances will increase the reliability of analytical diagnostics and reduce the likelihood of false positive results of the analysis. The use of a validated method of enzymatic hydrolysis of hair will eliminate unreliable results of the analysis due to the detection of the native molecule of the toxicant, increase the efficiency and accuracy of the diagnostic procedure.

【解决生物物体免疫层析检查时交叉反应问题的方法】。
本综述的目的是研究免疫层析法在实验室诊断初期几种药物(美贝弗林、苯尼布特、托品酰胺、雷米普利、美托洛尔、苯肾上腺素、舍曲林、氯吡敏、苯海拉明)交叉反应的原因,并提出一种可能的解决方法。进行头发研究以查明使用精神活性物质的事实,将提高分析诊断的可靠性,并减少分析产生假阳性结果的可能性。使用经过验证的头发酶解方法将消除由于检测有毒物质的天然分子而导致的不可靠分析结果,提高诊断程序的效率和准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sudebno-Meditsinskaya Ekspertisa
Sudebno-Meditsinskaya Ekspertisa Medicine-Pathology and Forensic Medicine
CiteScore
0.60
自引率
0.00%
发文量
70
期刊介绍: The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.
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