Association between Increased Uterine Activity, as Recorded Noninvasively from the Anterior Abdominal Wall at 34 Weeks' Gestation, and Preterm Birth.

Abstract

Background: There is a need to accurately identify pregnant women at risk for preterm birth as early as possible. Recent developments in technology enable the recording of uterine electrical activity (electrohysterogram) from the anterior abdominal wall in a non-invasive way.

Objective: To investigate whether uterine activity recorded under resting conditions at a gestational age of 34 weeks could identify a risk of preterm birth.

Study design: A commercial antenatal holter device with its dedicated software was used to record and store raw data of the maternal and fetal electrocardiograms and uterine activity for the Safe Passage Study. Uterine activity was recorded under resting conditions from 34 weeks' gestation in epochs of 250 ms (millisecond) for at least 30 min. From this database the raw data, recorded at a mean gestational age of 34 weeks, of 50 women who had preterm deliveries were selected for comparison with data of women who had term deliveries. Mean uterine activity, expressed in microvolt (μV)/epoch, was used for the comparison.

Results: After exclusion of 25 participants where labour was induced or augmented and another three for other reasons, 36 remained in each group. The participants in each group were comparable in respect of maternal age, gravidity, parity, gestational age at recruitment and duration of recording. Uterine activity in the preterm group (60.3 μV/epoch) differed significantly (p<0.01) from that of the comparison group (52.4 μV/epoch). Using a cut-off point of 52.3 μV/epoch as obtained from receiver operator characteristic curves (area under the curve 0.72), the sensitivity and specificity of identifying risks of preterm labour were 81% and 50% respectively.

Conclusion: Results of this small study are promising but need to be confirmed in larger studies and preferably at earlier gestational age.