An Aspirin a Day: New Pharmacological Developments and Cancer Chemoprevention.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
David G Menter, Robert S Bresalier
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引用次数: 6

Abstract

Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or prevent the progression or recurrence of cancer. A large body of preclinical and clinical data suggest the ability of aspirin to prevent precursor lesions and cancers, but much of the clinical data are inferential and based on descriptive epidemiology, case control, and cohort studies or studies designed to answer other questions (e.g., cardiovascular mortality). Multiple pharmacological, clinical, and epidemiologic studies suggest that aspirin can prevent certain cancers but may also cause other effects depending on the tissue or disease and organ site in question. The best-known biological targets of aspirin are cyclooxygenases, which drive a wide variety of functions, including hemostasis, inflammation, and immune modulation. Newly recognized molecular and cellular interactions suggest additional modifiable functional targets, and the existence of consensus molecular cancer subtypes suggests that aspirin may have differential effects based on tumor heterogeneity. This review focuses on new pharmacological developments and innovations in biopharmacology that clarify the potential role of aspirin in cancer chemoprevention.

一天一片阿司匹林:新的药理发展和癌症化学预防。
化学预防是指使用天然或合成药物来逆转、抑制或防止癌症的进展或复发。大量临床前和临床数据表明阿司匹林能够预防前驱病变和癌症,但大部分临床数据是推断性的,基于描述性流行病学、病例对照、队列研究或旨在回答其他问题(如心血管死亡率)的研究。多项药理学、临床和流行病学研究表明,阿司匹林可以预防某些癌症,但也可能导致其他影响,这取决于所涉及的组织或疾病和器官部位。阿司匹林最著名的生物学靶点是环加氧酶,它具有多种功能,包括止血、炎症和免疫调节。新认识的分子和细胞相互作用提示了其他可改变的功能靶点,并且存在一致的分子癌症亚型表明阿司匹林可能具有基于肿瘤异质性的不同作用。本文综述了生物药理学的新发展和创新,阐明了阿司匹林在癌症化学预防中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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