Autophagy in the retinal pigment epithelium: a new vision and future challenges.

IF 5.5 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
FEBS Journal Pub Date : 2022-11-01 DOI:10.1111/febs.16018
Daniela Intartaglia, Giuliana Giamundo, Ivan Conte
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引用次数: 20

Abstract

The retinal pigment epithelium (RPE) is a highly specialized monolayer of polarized, pigmented epithelial cells that resides between the vessels of the choriocapillaris and the neural retina. The RPE is essential for the maintenance and survival of overlying light-sensitive photoreceptors, as it participates in the formation of the outer blood-retinal barrier, phagocytosis, degradation of photoreceptor outer segment (POS) tips, maintenance of the retinoid cycle, and protection against light and oxidative stress. Autophagy is an evolutionarily conserved 'self-eating' process, designed to maintain cellular homeostasis. The daily autophagy demands in the RPE require precise gene regulation for the digestion and recycling of intracellular and POS components in lysosomes in response to light and stress conditions. In this review, we discuss selective autophagy and focus on the recent advances in our understanding of the mechanism of cell clearance in the RPE for visual function. Understanding how this catabolic process is regulated by both transcriptional and post-transcriptional mechanisms in the RPE will promote the recognition of pathological pathways in genetic disease and shed light on potential therapeutic strategies to treat visual impairments in patients with retinal disorders associated with lysosomal dysfunction.

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Abstract Image

Abstract Image

视网膜色素上皮细胞的自噬:一个新的愿景和未来的挑战。
视网膜色素上皮(RPE)是一种高度特化的单层极化着色上皮细胞,位于绒毛膜毛细血管和神经视网膜之间。RPE是维持和生存的基础上覆盖的光敏光感受器,因为它参与外血视网膜屏障的形成,吞噬,光感受器外段(POS)尖端的降解,维持类视黄醛循环,并防止光和氧化应激的保护。自噬是一种进化上保守的“自食”过程,旨在维持细胞稳态。RPE的日常自噬需求需要精确的基因调控来消化和回收溶酶体中的细胞内和POS成分,以响应光和应激条件。在这篇综述中,我们讨论了选择性自噬,并重点介绍了我们对RPE细胞清除视觉功能机制的最新研究进展。了解RPE中这种分解代谢过程是如何由转录和转录后机制调节的,将促进对遗传疾病病理途径的认识,并为治疗与溶酶体功能障碍相关的视网膜疾病患者的视力障碍提供潜在的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Journal
FEBS Journal 生物-生化与分子生物学
CiteScore
11.70
自引率
1.90%
发文量
375
审稿时长
1 months
期刊介绍: The FEBS Journal is an international journal devoted to the rapid publication of full-length papers covering a wide range of topics in any area of the molecular life sciences. The criteria for acceptance are originality and high quality research, which will provide novel perspectives in a specific area of research, and will be of interest to our broad readership. The journal does not accept papers that describe the expression of specific genes and proteins or test the effect of a drug or reagent, without presenting any biological significance. Papers describing bioinformatics, modelling or structural studies of specific systems or molecules should include experimental data.
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