SERKs and NIKs: Coreceptors or signaling hubs in a complex crosstalk between growth and defense?

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
Elizabeth P.B. Fontes
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引用次数: 0

Abstract

SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES (SERKs) and NUCLEAR SHUTTLE PROTEIN-INTERACTING KINASES (NIKs) belong to superfamily II of leucine-rich repeat receptor-like kinases, which share cytosolic kinase conservation and a similar ectodomain configuration. SERKs have been extensively demonstrated to function as coreceptors of receptor-like kinases, which sense biotic or developmental signals to initiate specific responses. NIKs, on the other hand, have emerged as downstream components in signaling cascades, not functioning as coreceptors but rather serving as hubs that converge information from both biotic and abiotic signals, resulting in a unified response. Like SERKs, NIKs play a crucial role as information spreaders in plant cells, forming hubs of high centrality. However, unlike SERKs, which function as coreceptors and assemble paired receptor-specific responses, NIKs employ a shared signaling circuit to transduce diverse biotic and abiotic signals into the same physiological response. Therefore, this review highlights the concept of signaling hubs that differ from coreceptors in signaling pathways.

SERKs 和 NIKs:生长与防御之间复杂串扰中的核心受体还是信号枢纽?
SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES(SERKs)和 NUCLEAR SHUTTLE PROTEIN-INTERACTING KINASES(NIKs)属于富亮氨酸重复受体样激酶超家族 II,它们共享细胞质激酶保护和相似的外结构域。SERKs 作为受体样激酶的核心受体,可感知生物或发育信号以启动特定反应,其功能已得到广泛证实。另一方面,NIKs 已成为信号级联中的下游成分,它们不是作为核心受体发挥作用,而是作为枢纽,汇聚来自生物和非生物信号的信息,从而产生统一的反应。与 SERKs 一样,NIKs 在植物细胞中也扮演着信息传播者的重要角色,形成高中心性枢纽。然而,与 SERKs 不同的是,NIKs 发挥核心受体的作用,并组装成对的受体特异性反应,而 NIKs 则采用共享信号回路,将不同的生物和非生物信号转导为相同的生理反应。因此,本综述强调了信号通路中不同于核心受体的信号枢纽概念。
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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