Harnessing potent therapies with care: enfortumab vedotin plus pembrolizumab for advanced-stage urothelial carcinoma

IF 81.1 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2023-09-04 DOI:10.1038/s41571-023-00814-6

Pooja Ghatalia, Elizabeth R. Plimack

引用次数: 0

Abstract

Following the recent FDA Accelerated Approval of enfortumab vedotin (EV) plus pembrolizumab for patients with advanced-stage urothelial carcinoma who are cisplatin-ineligible, herein we highlight key clinical outcomes with this combination based on results from Cohort K of the pivotal phase Ib/II EV-103 trial. We also discuss treatment sequencing, de-escalation strategies and toxicity management as EV–pembrolizumab becomes widely used in clinical practice.

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利用有效的治疗与护理:强制维多汀加派姆单抗晚期尿路上皮癌。

最近，美国 FDA 加速批准恩福单抗维多汀（EV）联合彭博利珠单抗用于治疗不符合顺铂治疗条件的晚期尿路上皮癌患者，我们在此根据关键的 EV-103 Ib/II 期试验 K 队列的结果，重点介绍这种联合疗法的主要临床结果。随着 EV-pembrolizumab 在临床实践中的广泛应用，我们还将讨论治疗排序、降级策略和毒性管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.