Anaplastic large cell lymphoma, ALK-positive in very young children: A long-term follow-up of two cases and a review of the literature.

IF 0.6 4区医学 Q4 PATHOLOGY

Malaysian Journal of Pathology Pub Date : 2022-12-01

T N Aladily, M Khader, N Bustami, F Bazzeh

引用次数: 0

Abstract

Anaplastic large cell lymphoma, ALK-positive is a mature T-cell neoplasm that accounts for 10- 20% of paediatric non-Hodgkin lymphoma. Its frequency in infants and very young children is exceedingly rare and was rarely documented in the literature. The disease prognosis in this agegroup is unknown. We report two male patients who were diagnosed with ALCL-ALK(+) at the ages of 12 and 14 months, both presented with fever and leukemoid reaction, one was in stage I and the other in stage IV diseases. They were treated with APO-based chemotherapy and remained in complete remission for more than 7 years. To our knowledge, this is the first report that describes the long-term survival of ALCL-ALK(+) at very young age.

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幼童alk阳性间变性大细胞淋巴瘤:两个病例的长期随访和文献回顾。

间变性大细胞淋巴瘤，alk阳性，是一种成熟的t细胞肿瘤，占儿科非霍奇金淋巴瘤的10- 20%。它在婴儿和幼儿中的发病率非常罕见，在文献中很少有记载。该年龄组的疾病预后尚不清楚。我们报告两名男性患者分别在12个月和14个月时被诊断为ALCL-ALK(+)，均表现为发烧和白血病样反应，一名为I期，另一名为IV期疾病。他们接受了基于apo的化疗，并保持了7年以上的完全缓解。据我们所知，这是第一个描述ALCL-ALK(+)在非常年轻时长期生存的报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Journal of Pathology PATHOLOGY-

CiteScore

3.60

自引率

5.60%

发文量

期刊介绍： The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.