DOSE RELATIONSHIP DURING RADIOABLATION OF THYROID RESIDUAL IN PATIENTS WITH THYROID DIFFERENTIATED CANCER.

Problemy radiatsiinoi medytsyny ta radiobiolohii Pub Date : 2022-12-01 DOI:10.33145/2304-8336-2022-27-431-439

D O Dzhuzha

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引用次数: 0

Abstract

Objective: to study relationship between the focal adsorbed doses (FAD) in the residual thyroid tissue (RTT) atradioiodine therapy (RIT) in patients with differentiated thyroid cancer (DTC) and efficacy of radioablation (RA).

Materials and methods: FAD in RTT in 221 patients aged 25-74 years were analyzed. Scintigraphic investigations were executed using gamma-camera «МВ 9200» and single photon emission tomograph «Е. САМ 180». FAD in RTT were determined according to recommendation of the Committee on Medical Internal Radiation Dose.

Results: Mean FAD in RTT was consisted (125.9 ± 8.6) Gy with range 1.8-1373.4 Gy. Positive effect after first course of RIT was in 77.4 % of patients complete RA of 78 % of RTT was achieved. Mean FAD in cases with complete RA was (147.0 ± 13.3) Gy with range 1.8-1373.4 Gy. Efficacy of RIT constantly increased from 68.2 to 93.7 % with increasing mean FAD from 30 to 370 Gy. Feather enlarging of FAD did not lead to any significant increasing of efficacy of RIT:enlarging mean FAD from 370 to 776 Gy increased efficacy of RA on 0.4 % only. Repeated RIT decreased FAD in RTTafter each course. Using regression analysis was established type of relationship between efficacy of RA and FAD in RTT, according it efficacy of first RA consists at 40 Gy 72.8 %, 150 Gy - 84.9 %, 300 Gy - 91.2 %, 400 Gy - 93.7 %,500 Gy - 95.7 %.

Conclusions: FAD in RTT at RIT differ in large range, it can be explained different anatomical and functional condition of iodine accumulate thyroid tissue after surgical treatment and its radioresistance. Efficacy of RA increases with enlarging of FAD, this relationship is nonlinear. Efficacy of RA has the upper dose threshold in range 350-400 Gy. The frequency of thyroid tissue with high radioresistance is approximately 6 %.

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甲状腺分化癌患者甲状腺残留放射消融的剂量关系。

目的:探讨分化型甲状腺癌(DTC)放射碘治疗(RIT)患者残留甲状腺组织(RTT)病灶吸附剂量(FAD)与放射消融(RA)疗效的关系。材料与方法:对221例25 ~ 74岁RTT患者的FAD进行分析。利用伽马照相机“МВ 9200”和单光子发射断层成像“Е”进行了扫描调查。САМ180»。RTT的FAD是根据医疗内辐射剂量委员会的建议确定的。结果:RTT的平均FAD为(125.9±8.6)Gy，范围为1.8 ~ 1373.4 Gy。首个疗程RIT后，77.4%的患者有正面疗效，78%的患者完成了RA治疗。完全性RA的平均FAD为(147.0±13.3)Gy，范围为1.8 ~ 1373.4 Gy。随着平均FAD从30 Gy增加到370 Gy, RIT的疗效从68.2持续增加到93.7%。FAD的羽毛增大并没有导致RIT疗效的显著增加:平均FAD从370 Gy增大到776 Gy, RA的疗效仅增加0.4%。每次疗程后，重复RIT均可降低rtt的FAD。通过回归分析，建立了RA与FAD在RTT中的疗效类型关系，其中第一次RA的疗效为40 Gy - 72.8%， 150 Gy - 84.9%， 300 Gy - 91.2%， 400 Gy - 93.7%，500 Gy - 95.7%。结论:RIT患者的FAD差异较大，可以解释手术后甲状腺组织碘积聚的解剖和功能状况及其放射抵抗的差异。RA的疗效随FAD的增大而增加，且呈非线性关系。RA的疗效上剂量阈值在350-400 Gy。甲状腺组织具有高辐射电阻的频率约为6%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Problemy radiatsiinoi medytsyny ta radiobiolohii Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.60

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0.00%

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