Role of Candida albicans in Oral Carcinogenesis.

IF 2.7 Q2 PATHOLOGY

Pathophysiology Pub Date : 2022-12-07 DOI:10.3390/pathophysiology29040051

Nurina Febriyanti Ayuningtyas, Fatma Yasmin Mahdani, Togu Andrie Simon Pasaribu, Muhammad Chalim, Visilmi Kaffah Putri Ayna, Arvind Babu Rajendra Santosh, Luigi Santacroce, Meircurius Dwi Condro Surboyo

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引用次数: 8

Abstract

Oral carcinogenesis is also dependent on the balance of the oral microbiota. Candida albicans is a member oral microbiota that acts as an opportunistic pathogen along with changes in the epithelium that can predispose to premalignancy and/or malignancy. This systematic review uses the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to analyze the role of Candida albicans in the process of oral carcinogenesis. Eleven articles qualified inclusion criteria, matched keywords, and provided adequate information about the carcinogenesis parameters of Candida albicans in oral cancer. Candida albicans in oral carcinogenesis can be seen as significant virulent factors for patients with oral squamous cell carcinoma (OSCC) or potentially malignant disorder (OPMD) with normal adjacent mucosa. Candida albicans have a role in the process of oral carcinogenesis concerning morphological phenotype changes in cell structure and genotype and contribute to the formation of carcinogenic substances that can affect cell development towards malignancy.

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白色念珠菌在口腔癌变中的作用。

口腔癌的发生也依赖于口腔微生物群的平衡。白色念珠菌是口腔微生物群的一员，它作为一种机会性病原体，伴随着上皮的变化，可导致恶性前病变和/或恶性肿瘤。本系统综述采用系统综述和荟萃分析指南的首选报告项目来分析白色念珠菌在口腔癌变过程中的作用。11篇文章符合纳入标准，匹配关键词，并提供了口腔癌中白色念珠菌致癌参数的足够信息。口腔白色念珠菌是口腔鳞状细胞癌(OSCC)或邻近粘膜正常的潜在恶性疾病(OPMD)患者的重要致病因素。白色念珠菌在口腔癌变过程中涉及细胞结构和基因型的形态学表型改变，并促进致癌物质的形成，影响细胞向恶性发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathophysiology Medicine-Pathology and Forensic Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.