{"title":"An Update on Potential Antidepressants Derived from Marine Natural Products.","authors":"Priya P Shejul, Radhika K Raheja, Gaurav M Doshi","doi":"10.2174/1871524923666230825105035","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Depression is one of the most frequently occurring psychiatric disorders worldwide, affecting 121 million worldwide. World Health Organization (WHO) estimates that it is the leading cause of disability and the fourth leading contributor to the \"global burden of diseases\".</p><p><strong>Objective: </strong>Investigating and developing a drug with a novel benefit-risk profile is critical. Marine sources have been explored for their benefits as an alternative therapy for depression treatment. Numerous studies have shown that natural compounds containing peptides, alkaloids, polyphenols, diterpenes, glycosides, vitamins, and minerals from marine sources can potentially treat a wide range of disorders, including depression. Such phytoconstituents are known to reduce oxidative stress and neuroinflammation, regulate the synthesis or function of neurotransmitters such as glutamate and acetylcholinesterase, and aid in enhancing serotonin levels and nerve development.</p><p><strong>Methods: </strong>In this review study, a literature search was conducted using terms often used, including animal models of depression and their precise phases, marine sources, algae, sponges, and indole alkaloids. Additionally, databases were examined, including Scopus, Wiley, Elsevier, Google Scholar, and Web of Science. The Snowball technique was used to identify several articles about depression but correlated to marine sources in addition to database searches.</p><p><strong>Results: </strong>Current antidepressant medications have several negative side effects on the human body, including dry mouth, cardiovascular interference, gastrointestinal symptoms, genitourinary symptoms, hepatotoxicity, convulsions, and obesity. As a result, researchers can identify a wide range of potential targets for medications derived from marine sources. A combination of marinederived drugs and available treatments can be estimated to minimize the negative effects. So that these resources can be used as efficiently as possible, and various marine-derived substances can be studied for therapeutic efficacy.</p><p><strong>Conclusion: </strong>This review focuses on the preclinical and clinical findings of marine-derived compounds with antidepressant properties that alter behavioural parameters and biochemical abnormalities, as well as their mechanism of action and in-vivo potential.</p>","PeriodicalId":9799,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871524923666230825105035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Depression is one of the most frequently occurring psychiatric disorders worldwide, affecting 121 million worldwide. World Health Organization (WHO) estimates that it is the leading cause of disability and the fourth leading contributor to the "global burden of diseases".
Objective: Investigating and developing a drug with a novel benefit-risk profile is critical. Marine sources have been explored for their benefits as an alternative therapy for depression treatment. Numerous studies have shown that natural compounds containing peptides, alkaloids, polyphenols, diterpenes, glycosides, vitamins, and minerals from marine sources can potentially treat a wide range of disorders, including depression. Such phytoconstituents are known to reduce oxidative stress and neuroinflammation, regulate the synthesis or function of neurotransmitters such as glutamate and acetylcholinesterase, and aid in enhancing serotonin levels and nerve development.
Methods: In this review study, a literature search was conducted using terms often used, including animal models of depression and their precise phases, marine sources, algae, sponges, and indole alkaloids. Additionally, databases were examined, including Scopus, Wiley, Elsevier, Google Scholar, and Web of Science. The Snowball technique was used to identify several articles about depression but correlated to marine sources in addition to database searches.
Results: Current antidepressant medications have several negative side effects on the human body, including dry mouth, cardiovascular interference, gastrointestinal symptoms, genitourinary symptoms, hepatotoxicity, convulsions, and obesity. As a result, researchers can identify a wide range of potential targets for medications derived from marine sources. A combination of marinederived drugs and available treatments can be estimated to minimize the negative effects. So that these resources can be used as efficiently as possible, and various marine-derived substances can be studied for therapeutic efficacy.
Conclusion: This review focuses on the preclinical and clinical findings of marine-derived compounds with antidepressant properties that alter behavioural parameters and biochemical abnormalities, as well as their mechanism of action and in-vivo potential.
引言:抑郁症是全球最常见的精神疾病之一,影响着全球1.21亿人。世界卫生组织(世界卫生组织)估计,它是残疾的主要原因,也是“全球疾病负担”的第四大贡献者。海洋资源已被探索作为抑郁症治疗的替代疗法的好处。大量研究表明,含有肽、生物碱、多酚、二萜、糖苷、维生素和海洋来源矿物质的天然化合物有可能治疗包括抑郁症在内的多种疾病。已知这些植物成分可以减少氧化应激和神经炎症,调节谷氨酸和乙酰胆碱酯酶等神经递质的合成或功能,并有助于提高血清素水平和神经发育。方法:在这项综述研究中,使用常用的术语进行文献检索,包括抑郁症的动物模型及其确切阶段、海洋来源、藻类、海绵和吲哚生物碱。此外,还对Scopus、Wiley、Elsevier、Google Scholar和Web of Science等数据库进行了检查。雪球技术被用来识别几篇关于抑郁症的文章,但除了数据库搜索外,还与海洋来源有关。结果:目前的抗抑郁药物对人体有几种负面副作用,包括口干、心血管干扰、胃肠道症状、泌尿生殖系统症状、肝毒性、抽搐和肥胖。因此,研究人员可以确定海洋来源药物的广泛潜在靶点。可以估计,将海洋药物和可用的治疗方法相结合,可以最大限度地减少负面影响。以便尽可能有效地利用这些资源,并研究各种海洋衍生物质的治疗效果。结论:这篇综述的重点是具有抗抑郁特性的海洋衍生化合物的临床前和临床发现,这些化合物会改变行为参数和生化异常,以及它们的作用机制和体内潜力。
期刊介绍:
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.