One-pot multicomponent reaction: An efficient synthesis of 4-(HET)Aryl-substituted pyrazolo-quinolinones.

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Current organic synthesis Pub Date : 2023-08-21 DOI:10.2174/1570179421666230821102745

Hüseyin Kerim Beker, Şeniz Kaban

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引用次数: 0

Abstract

Introduction: Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it was found that they have very advanced functionally promising as selective compounds due to their scaffold and demonstrated low toxicity and considerable clinical promise. Moreover, these compounds have an important role in different applications such as analytical reagents, technical, pharmaceutical development, and biological markers. So, we aimed to synthesize and characterize new 4-(Het)aryl-substituted Pyrazole-quinolinones.

Method: Synthesis of One-Pot Multicomponent Reaction was carried out with the reaction of 5-amino-3-methyl-1H-pyrazole 1a, and 5-amino-3-phenyl-1H-pyrazole 1b and dimedone 2 with some (het)aryl aldehydes 3 using ethanol. Characterizations such as the linear structures and the regiospecificity of the reactions were determined by using NMR, GC-MS, IR, and UV measurements.

Conclusion: This research will be very useful for all methods and procedures using multi-one-point reactions which are very popular in the synthesis of heterocyclic systems for pyrazole- quinoline skeleton synthesis.

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一锅多组分反应:4-(HET)芳基取代吡唑喹啉酮的高效合成。

吡唑啉喹诺啉酮(PQs)是一类用途广泛的有机化合物，由于其支架结构和低毒性，作为选择性化合物被发现具有非常先进的功能前景和相当大的临床应用前景。此外，这些化合物在分析试剂，技术，药物开发和生物标记等不同应用中具有重要作用。因此，我们旨在合成并表征新的4-(et)芳基取代吡唑-喹啉酮类化合物。方法:以5-氨基-3-甲基- 1h -吡唑1a、5-氨基-3-苯基- 1h -吡唑1b和二美酮2为原料，用乙醇与部分芳基醛3反应，进行一锅多组分反应合成。通过NMR, GC-MS, IR和UV测量确定了反应的线性结构和区域特异性等表征。结论:本研究对吡唑-喹啉骨架合成中常用的多一点反应的合成方法和步骤有一定的指导意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current organic synthesis 化学-有机化学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.